Description
STEARDA inhibits arachidonate 5-LO (5-lipoxygenase) with an IC:50:of 16 nM. Adiditionally, is an ndogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. STEARDA is inactive at TRPV1 and CB1 receptors (at concentrations up to 5 µM) and does not inhibit AMT or FAAH (IC50 > 25 µM). However, STEARDA potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also, STEARDA inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).application：STEARDA is a novel, endogenous capsaicin-like lipid that produces hyperalgesia